Positive KCa Channel Gating Modulators with Selectivity for KCa3.1
نویسندگان
چکیده
منابع مشابه
New Positive Ca 2 1 - Activated K 1 Channel Gating Modulators with Selectivity for KCa 3 . 1 s
Small-conductance (KCa2) and intermediate-conductance (KCa3.1) calcium-activated K channels are voltage-independent and share a common calcium/calmodulin-mediated gating mechanism. Existing positive gating modulators like EBIO, NS309, or SKA-31 activate both KCa2 and KCa3.1 channels with similar potency or, as in the case of CyPPA and NS13001, selectively activate KCa2.2 and KCa2.3 channels. We...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.134